Folic acid is a water-soluble vitamin with the formula C19H19N7O6. It is named for its rich content in green leaves, also known as pteroylglutamic acid. There are several forms in nature, and its parent compound is a combination of pteridine, p-aminobenzoic acid and glutamic acid.
| Product Name |
Folic acid |
| Purity |
99.0%min |
| Product Grade |
Food Grade; Pharmaceutical Grade |
| Classification |
Vitamins |
| Appearance |
Light yellow crystalline powder |
Medical application
Existing studies have reported that folic acid plays an extremely important role in human health. Folic acid deficiency can lead to the risk of neurological malformation in newborns, thrombotic occlusive heart and cerebrovascular diseases, anorexia and anorexia nervosa, megaloblastic anemia, vascular dementia in the elderly, depression and other diseases.
(1) The effect of folic acid on neural tube malformation in neonates
A study of folic acid supplementation from diet and nutritional supplements in the United States between 2003 and 2006 shows that folic acid intake of women of childbearing age must be improved. In areas with high NTDs prevalence, the daily amount of folic acid provided to pregnant women is only 100μg, which is far below the daily requirement of pregnant women.
A study on the effect of dietary folic acid intake on blood folic acid content in lactating women in Canada concluded that lactating women should consume 400μg of folic acid per day. Folic acid plays an important role in regulating neurogenesis and programmed cell death.
In the United States, folic acid supplementation was associated with a 19 percent decrease in the birth rate of babies with neurological closure defects, although other factors were not excluded from the decrease.
0.4 mg of folic acid is used to prevent neural tube malformations in the fetus. The Salian Folic acid Project has been verified by the 250,000 cases of Sino-US cooperation on the prevention of neural tube malformations in the country. Taking 0.4 mg of folic acid during pregnancy can reduce the rate of neural tube malformations in the fetus by 85%, which has been widely used in more than 50 countries around the world. 5 mg of folic acid is used to treat female anemia, consumers must carefully look at the instructions when choosing to buy, according to different circumstances to choose.
(2) Study on the effects of folic acid on other human diseases
In addition to the effect of folic acid on the prevention of incomplete nerve closure in infants, it also plays a certain role in the prevention of some common diseases in humans.
(3) Study on the effects of folic acid on other diseases
The increase of plasma homocysteine concentration can lead to thrombotic obliterated heart and cerebrovascular diseases, anorexia and anorexia nervosa, senile vascular dementia, depression and other diseases. Folic acid is an important cofactor in the cyclic metabolism of homocysteine. Folic acid can be converted into 5, 10-methylene tetrahydrofolate by activation, which provides methyl for the conversion of homocysteine to methionine. Folic acid deficiency leads to the accumulation of a large amount of homocysteine, which is excreted outside the cell, resulting in increased plasma homocysteine concentration, leading to disease. Studies have shown that the consumption of folic acid fortified foods has an essential relationship with the increase of serum folic acid level in middle-aged and elderly people. Folic acid may reduce the risk of gout in people who have no history of gout. Folic acid deficiency can cause damage to many systems in the body, mainly in the digestive system, colitis, chronic atrophic gastritis, and increase the risk of colon and stomach cancer. Folic acid supplements can inhibit the recurrence rate of colorectal cancer.
Studies have shown that a certain concentration of folic acid can inhibit the growth of ovarian cancer cells by affecting folic acid metabolism, and folic acid may enhance the cytotoxic effect of chemotherapy drugs on ovarian cancer, thus enhancing the sensitivity of ovarian cancer chemotherapy.
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Xi'an Jianyuan Chemical Co., Ltd. is specializing in Raw Materials of Chemical, Pharmaceutical and Food industries over than 5 years in China. Our business covers more than 100 countries in America, Europe, Middle East and other areas.
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